English publication 'The Guardian' reports that the Chilean will be named in the starting lineup for the game after German playmaker Mesut Ozil was ruled out through injury.
Ozil has joined a growing injury list, with Laurent Koscielny, Nacho Monreal, Sead Kolasinac, Aaron Ramsey and Olivier Giroud all currently sidelined.
The injury crisis has somewhat forced Wenger's hand, meaning that he is expected to field Sanchez, despite the club having received a £20m bid from runaway Premier League leaders Manchester City for the star.
City have been trying to sign Sanchez for some time now, having originally seen a £60m deadline day move collapse in the summer when Arsenal failed to secure a replacement.
However, with Sanchez now into the last six months of his contract and with talk of a £250,000 per week contract waiting for him at the Etihad, it appears City may finally get their man.