"It definitely helps us because we have played well there," Vertonghen said.
"We've beaten some big teams there and had some very good games, apart from the start of the season when it was a bit difficult for us.
"Juventus wasn't great, but Wembley suits us and we've had a good season there. We really feel at home there."
Vertonghen went on to dispel claims that rival teams should be upset over the arrangement, given the advantage that Tottenham will have in the cup.
"Everyone agreed that we had to play at Wembley, so I don't think teams would see it that way," he added
"At the beginning of the season everyone was talking about it (Spurs' poor Wembley form) - after the Chelsea, Burnley and West Brom games."
Tottenham will join Manchester United, Southampton and the winner of Chelsea v Leicester in the FA Cup semi finals.