Arsenal:
Arsene Wenger's men have won their last 12 on the bounce at home, but they will be without striker Alexandre Lacazette when they welcome second-placed United.
The France international suffered a groin injury against Huddersfield on Wednesday and has since been ruled out of tomorrow's heavyweight encounter.
Alexis Sanchez was also substituted in the Huddersfield win due to a hamstring problem, but Wenger is confident he will be fit.
Manchester United:
Jose Mourinho hasn't won any of his last 11 away league games against 'big six' opposition and his team’s midfield is looking thin ahead of their trip to north London.
Nemanja Matic was forced off in the 4-2 win over Watford midweek but could return, while Marouane Fellaini is a doubt after missing the clash against the Hornets entirely.
Defensive duo Phil Jones and Eric Bailly are out injured.
Recent form:
Possible lineups:
Arsenal: Cech; Koscielny, Mustafi, Monreal; Bellerin, Xhaka, Ramsey, Kolasinac; Ozil, Sanchez, Welbeck
Manchester United: De Gea; Valencia, Smalling, Lindelof, Young; Herrera, Matic, Pogba; Martial, Lukaku, Lingard